One of the oldest Macedonian clubs, Kozhuf from Gevgelija, officially got relegated to the fourth league together with Sirkovo.
Kozhuf – Prevalec 0:1
Golemo Konjari – Sirkovo 4:0
Babuna – Ilinden 1955 1:0
Mladost Udovo – Rosoman 83 3:0
Partizan – Mlekar 0:0
Mladost Krivogashtani, Vardar Negotino and Varosh were free.
| Pl. | W | D | L | +/- | P | |||
| Vardar Negotino | 20 | 13 | 3 | 4 | 53:19 | 42 | play-off | |
| Babuna | 21 | 13 | 3 | 5 | 37:20 | 42 | ||
| Partizan | 22 | 10 | 6 | 6 | 39:23 | 39 | ||
| Mladost Udovo | 22 | 9 | 9 | 4 | 38:20 | 36 | ||
| Varosh | 20 | 11 | 3 | 6 | 33:18 | 36 | ||
| Golemo Konjari | 21 | 10 | 5 | 6 | 31:19 | 35 | ||
| Mlekar | 21 | 9 | 8 | 4 | 29:18 | 35 | (relegation) | |
| Prevalec | 22 | 8 | 4 | 10 | 23:36 | 28 | (relegation) | |
| Mladost Krivogashtani | 21 | 7 | 3 | 11 | 33:59 | 24 | (relegation) | * |
| Ilinden 1955 | 20 | 7 | 1 | 12 | 24:33 | 22 | (relegation) | * |
| Kadino | 13 | 6 | 1 | 6 | 27:34 | 19 | relegated | |
| Rosoman 83 | 20 | 6 | 2 | 12 | 28:44 | 17 | relegation | -3 |
| Sirkovo | 22 | 3 | 3 | 17 | 18:51 | 12 | relegated | |
| Kozhuf | 21 | 3 | 3 | 15 | 25:47 | 9 | relegated | -3 |
^ From next season all 3rd Leagues will feature 12 teams, so this season will see more teams get relegated. Also, the correct number of relegated teams will be known after the conclusion of the Second League as it depends how many teams from there will be relegated into each third league. Currently in the Second League, there are 4 teams that in case of relegation will join the South (11 Oktomvri, Borec, Miravci and Pobeda Junior).
* Kadino is disqualified for not appearing in two games and all of their second half-season results got erased.
* 11 Oktomvri and Borec got relegated from the Second League.
Round 26 is scheduled for 4 May at 17.00 CET:
Vardar Negotino vs. Mladost Udovo
Rosoman 83 vs. Babuna
Ilinden 1955 vs. Varosh
Sirkovo vs. Kozhuf
Prevalec vs. Mladost Krivogashtani
Golemo Konjari, Mlekar and Partizan are free.