Osogovo beat Napredok in Radovo, Babi got defeated by Cheshinovo, while Sasa beat Karbinci and sent them into the fourth league.
Cheshinovo – Babi 4:2
Sloga 1934 – Rabotnik Djumajlija 3:1
Sasa – Karbinci 3:1
Napredok Radovo – Osogovo 0:1
Astibo – Belasica postponed for Wednesday due to flooded field
Bregalnica Golak – Rudar 6:0
Trkanja – Plachkovica 0:0
Round 22 postponed game that was played on Wednesday:
Osogovo – Astibo 4:0
| Pl. | W | D | L | +/- | P | |||
| Belasica | 22 | 19 | 1 | 2 | 70:13 | 58 | play-off | |
| Sloga 1934 | 23 | 17 | 2 | 4 | 48:26 | 53 | ||
| Napredok Radovo | 23 | 15 | 1 | 8 | 58:30 | 46 | ||
| Osogovo | 23 | 14 | 3 | 6 | 57:28 | 45 | ||
| Bregalnica Golak | 23 | 14 | 3 | 6 | 47:25 | 45 | ||
| Babi | 23 | 12 | 3 | 8 | 40:27 | 33 | -6 | |
| Sasa | 23 | 9 | 5 | 9 | 41:37 | 32 | ||
| Plachkovica | 22 | 9 | 6 | 7 | 35:36 | 32 | ||
| Cheshinovo | 23 | 8 | 0 | 15 | 43:64 | 24 | ||
| Rabotnik Djumajlija | 23 | 7 | 2 | 14 | 34:59 | 23 | (relegation) | |
| Trkanja | 23 | 7 | 4 | 12 | 33:42 | 22 | relegation | -3 |
| Astibo | 22 | 4 | 3 | 15 | 23:50 | 15 | relegation | |
| Karbinci | 23 | 4 | 2 | 17 | 18:61 | 14 | relegated | |
| Rudar | 22 | 2 | 2 | 18 | 23:72 | 5 | relegated | -3 |
* From next season, all 3rd Leagues will feature 12 teams, so more teams will be relegated this campaign. The precise number of relegated teams will be known after the conclusion of the Second League as it depends how many teams from there will be relegated into each third league. Currently in the Second League, there is 1 team (Tiverija) that in case of relegation will join the East.
Round 24 is scheduled for 11 May at 16.30 CET:
Babi vs. Trkanja
Plachkovica vs. Bregalnica Golak
Rudar vs. Astibo
Belasica vs. Napredok Radovo
Osogovo vs. Sasa
Karbinci vs. Sloga 1934
Rabotnik Djumajlija vs. Cheshinovo