| 12th November 2016, 20.45 CET | |||
 SPAIN 4:0 MACEDONIA  |
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| HT 1:0 | |||
| Goals: 34′ (og) Darko Velkovski, 63′ Vitolo Machín, 84′ Nacho Monreal, 85′ Aritz Aduriz | |||
| Stadium: Nuevo Los Cármenes in Granada |
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| Attendance: 23.000 | |||
| ESP | MKD | ||
| 1. | David de Gea Quintana (GK) | 1. | Stole Dimitrievski (GK) |
| 4. | Marc Bartra i Aregall | 4. | Kire Ristevski |
| 5. | Sergio Busquets i Burgos | 5. | Daniel Mojsov |
| 6. | José Ignacio Fernández Iglesias | 7. | Enis Bardi |
| 7. | Álvaro Borja Morata Martín  60′ |
8. | Ezgjan Alioski  90’+2 |
| 8. | Koke Resurrección Merodio 71′ |
9. | Ilija Nestorovski 82′ |
| 10. | Thiago Alcântara do Nascimento | 10. | Goran Pandev (C) |
| 11. | Vitolo Machín Pérez 87′ |
11. | Ferhan Hasani 87′ |
| 15. | Daniel “Dani” Carvajal Ramos | 13. | Stefan Ristovski |
| 18. | Ignacio “Nacho” Monreal Eraso | 14. | Darko Velkovski |
| 21. | David Josué Jiménez Silva (C) | 20. | Stefan Spirovski 60′ |
| Substitutes: | |||
| 2. | César Azpilicueta Tanco | 3. | Leonard Zhuta  60′ |
| 3. | Sergi Roberto i Carnicer | 6. | Vanche Shikov |
| 9. | Aritz Aduriz Zubeldia 60′ |
12. | Filip Gachevski (GK) |
| 12. | Sergio Asenjo Andrés (GK) | 15. | Gjoko Zajkov |
| 13. | Juan Manuel Mata García | 16. | Boban Nikolov |
| 14. | José María Callejón Bueno 87′ |
17. | Nikola Gjorgjev 87′ |
| 16. | Iñigo Martínez Berridi | 18. | David Babunski |
| 17. | Ander Herrera Agüera | 21. | Kire Markoski |
| 19. | Iago Aspas Juncal | 23. | Besart Ibraimi 82′ |
| 20. | Manuel Agudo Durán “Nolito” | / | |
| 22. | Francisco “Isco” Román Alarcón Suárez 71′ |
/ | |
| 23. | José Manuel “Pepe” Reina Páez (GK) | / | |
| Coaches: | |||
| Julen Lopetegui Agote |
Igor Angelovski |
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| Officials: | |||
Referee: Robert Schörgenhofer  |
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| Assistants: Maximilian Kolbitsch, Andreas Heidenreich |
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| Fourth Official: Dominik Ouschan |
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NOTE: 22. Igor Aleksovski was the original starting keeper for Macedonia, but got injured during the pre-match warm up and later didn’t even make the bench.
Highlights: